Drug interactions
Ifosfamide + Ustekinumab
Severity: Moderate
Ifosfamide and Ustekinumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide causes myelosuppression and immunosuppression, which may add to the immune modulation from ustekinumab. This may increase the risk of infection.
What this interaction means in plain words
Ifosfamide and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Ustekinumab belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression from cytotoxic chemotherapy and cytokine blockade.
What to do
Monitor blood counts and for infection during chemotherapy. Consider holding ustekinumab during severe neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Ustekinumab?
MediHelp rates the interaction as moderate. Ifosfamide and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ifosfamide causes myelosuppression and immunosuppression, which may add to the immune modulation from ustekinumab. This may increase the risk of infection.
How serious is the interaction between Ifosfamide and Ustekinumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for infection during chemotherapy. Consider holding ustekinumab during severe neutropenia.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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