Drug interactions
Ifosfamide + Vancomycin
Severity: Moderate
Ifosfamide and Vancomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide commonly causes proximal tubular injury and can cause renal failure, and vancomycin adds nephrotoxic risk. Ototoxicity risk from both agents may also be additive.
What this interaction means in plain words
Ifosfamide and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Vancomycin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxicity and possible additive ototoxicity.
What to do
Monitor serum creatinine, electrolytes and urine output regularly, and use vancomycin level-guided dosing. Consider alternatives to vancomycin when feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Vancomycin?
MediHelp rates the interaction as moderate. Ifosfamide and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ifosfamide commonly causes proximal tubular injury and can cause renal failure, and vancomycin adds nephrotoxic risk. Ototoxicity risk from both agents may also be additive.
How serious is the interaction between Ifosfamide and Vancomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, electrolytes and urine output regularly, and use vancomycin level-guided dosing. Consider alternatives to vancomycin when feasible.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.
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