Drug interactions
Ifosfamide + Verapamil
Severity: Moderate
Ifosfamide and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide is activated partly by CYP3A4 and 2B6, and verapamil may reduce formation of its active metabolites while increasing neurotoxic chloroacetaldehyde formation less so. The overall clinical impact is uncertain.
What this interaction means in plain words
Ifosfamide and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4, which may alter the bioactivation of ifosfamide.
What to do
Monitor for treatment response and ifosfamide toxicity, including neurotoxicity. Consider an alternative antihypertensive if efficacy is a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Verapamil?
MediHelp rates the interaction as moderate. Ifosfamide and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ifosfamide is activated partly by CYP3A4 and 2B6, and verapamil may reduce formation of its active metabolites while increasing neurotoxic chloroacetaldehyde formation less so. The overall clinical impact is uncertain.
How serious is the interaction between Ifosfamide and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for treatment response and ifosfamide toxicity, including neurotoxicity. Consider an alternative antihypertensive if efficacy is a concern.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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