Drug interactions
Ifosfamide + Voclosporin
Severity: Moderate
Ifosfamide and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can injure the kidney: ifosfamide through tubular toxicity and voclosporin through calcineurin inhibitor-related hemodynamic effects. Combined use may increase the risk of acute or chronic renal impairment.
What this interaction means in plain words
Ifosfamide and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Voclosporin belongs to Miscellaneous.
Why it happens
Additive nephrotoxicity through different renal mechanisms.
What to do
Monitor serum creatinine, eGFR and electrolytes closely. Reduce or interrupt voclosporin if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Ifosfamide with Voclosporin?
MediHelp rates the interaction as moderate. Ifosfamide and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can injure the kidney: ifosfamide through tubular toxicity and voclosporin through calcineurin inhibitor-related hemodynamic effects. Combined use may increase the risk of acute or chronic renal impairment.
How serious is the interaction between Ifosfamide and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, eGFR and electrolytes closely. Reduce or interrupt voclosporin if renal function declines.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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