Drug interactions
Ifosfamide + Voxelotor
Severity: Moderate
Ifosfamide and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor is a moderate CYP3A4 inhibitor. Ifosfamide is a CYP3A4-dependent prodrug, so exposure to its active and toxic metabolites could be altered. The clinical significance has not been well studied, and voxelotor is rarely given with ifosfamide.
What this interaction means in plain words
Ifosfamide and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibits CYP3A4, which may alter ifosfamide bioactivation and formation of neurotoxic chloroacetaldehyde.
What to do
Monitor for neurotoxicity, renal toxicity and treatment response during ifosfamide therapy. Consider an alternative to voxelotor if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Ifosfamide with Voxelotor?
MediHelp rates the interaction as moderate. Ifosfamide and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor is a moderate CYP3A4 inhibitor. Ifosfamide is a CYP3A4-dependent prodrug, so exposure to its active and toxic metabolites could be altered. The clinical significance has not been well studied, and voxelotor is rarely given with ifosfamide.
How serious is the interaction between Ifosfamide and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neurotoxicity, renal toxicity and treatment response during ifosfamide therapy. Consider an alternative to voxelotor if toxicity occurs.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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