Drug interactions
Ifosfamide + Zidovudine
Severity: Moderate
Ifosfamide and Zidovudine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide is a myelosuppressive alkylating agent, and zidovudine commonly causes anemia and neutropenia. Combined use can deepen cytopenias and raise the risk of infection or bleeding.
What this interaction means in plain words
Ifosfamide and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Zidovudine belongs to Anti Virals.
Why it happens
Additive bone marrow suppression (pharmacodynamic synergism).
What to do
Check complete blood counts before each chemotherapy cycle and frequently during treatment. Consider substituting a non-myelosuppressive antiretroviral such as tenofovir-based therapy during chemotherapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zidovudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Zidovudine?
MediHelp rates the interaction as moderate. Ifosfamide and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ifosfamide is a myelosuppressive alkylating agent, and zidovudine commonly causes anemia and neutropenia. Combined use can deepen cytopenias and raise the risk of infection or bleeding.
How serious is the interaction between Ifosfamide and Zidovudine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check complete blood counts before each chemotherapy cycle and frequently during treatment. Consider substituting a non-myelosuppressive antiretroviral such as tenofovir-based therapy during chemotherapy.
What other medicines interact with Zidovudine?
MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Atidarsagene autotemcel. The full list is on the Zidovudine page.
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