Drug interactions
Iloperidone + Indapamide
Severity: Major
Iloperidone and Indapamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone prolongs the QTc interval, and indapamide can add to this through electrolyte depletion and its own QT effect. This raises the risk of torsade de pointes, particularly with hypokalemia.
What this interaction means in plain words
Iloperidone and Indapamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Iloperidone belongs to Central Nervous System; Indapamide belongs to Cardiovascular.
Why it happens
Additive QTc prolongation, with diuretic-related hypokalemia and hypomagnesemia.
What to do
Avoid if possible; otherwise monitor ECG and keep potassium and magnesium within normal range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indapamide
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Indapamide?
MediHelp rates the interaction as major. Iloperidone and Indapamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Iloperidone prolongs the QTc interval, and indapamide can add to this through electrolyte depletion and its own QT effect. This raises the risk of torsade de pointes, particularly with hypokalemia.
How serious is the interaction between Iloperidone and Indapamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor ECG and keep potassium and magnesium within normal range.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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