Drug interactions
Iloperidone + Insulin detemir
Severity: Moderate
Iloperidone and Insulin detemir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics may cause hyperglycemia and weight gain, which can worsen glycemic control in insulin-treated patients. Iloperidone has a relatively modest metabolic risk.
What this interaction means in plain words
Iloperidone and Insulin detemir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Insulin detemir belongs to Endocrine.
Why it happens
Atypical antipsychotics may induce insulin resistance and impair glucose regulation; the mechanism is incompletely understood.
What to do
Monitor blood glucose and HbA1c after starting iloperidone. Titrate insulin detemir dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin detemir
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Insulin detemir?
MediHelp rates the interaction as moderate. Iloperidone and Insulin detemir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atypical antipsychotics may cause hyperglycemia and weight gain, which can worsen glycemic control in insulin-treated patients. Iloperidone has a relatively modest metabolic risk.
How serious is the interaction between Iloperidone and Insulin detemir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting iloperidone. Titrate insulin detemir dose accordingly.
What other medicines interact with Insulin detemir?
MediHelp also lists interactions of Insulin detemir with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin detemir page.
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