Drug interactions
Iloperidone + Insulin lispro
Severity: Moderate
Iloperidone and Insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics such as iloperidone can cause hyperglycemia and weight gain, which may worsen glycemic control in insulin-treated patients. Insulin requirements may rise.
What this interaction means in plain words
Iloperidone and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Insulin lispro belongs to Endocrine.
Why it happens
Antipsychotic-induced insulin resistance and metabolic effects oppose the action of insulin.
What to do
Check glucose regularly after starting iloperidone and increase the insulin dose as needed. Monitor weight and HbA1c over time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin lispro
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Insulin lispro?
MediHelp rates the interaction as moderate. Iloperidone and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atypical antipsychotics such as iloperidone can cause hyperglycemia and weight gain, which may worsen glycemic control in insulin-treated patients. Insulin requirements may rise.
How serious is the interaction between Iloperidone and Insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check glucose regularly after starting iloperidone and increase the insulin dose as needed. Monitor weight and HbA1c over time.
What other medicines interact with Insulin lispro?
MediHelp also lists interactions of Insulin lispro with, for example, Alogliptin-pioglitazone, Ethanol, Metreleptin. The full list is on the Insulin lispro page.
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