Drug interactions
Iloperidone + Ketamine
Severity: Moderate
Iloperidone and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is a weak CYP3A inhibitor and may modestly raise ketamine concentrations, and both drugs also cause sedation and can lower blood pressure. This may increase drowsiness, dizziness and orthostatic effects.
What this interaction means in plain words
Iloperidone and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Ketamine belongs to Central Nervous System.
Why it happens
Mild CYP3A4 inhibition by iloperidone plus additive CNS depressant and hypotensive effects.
What to do
Monitor sedation and blood pressure during co-use. Reduce the ketamine dose if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Iloperidone and Ketamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ketamine
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Ketamine?
MediHelp rates the interaction as moderate. Iloperidone and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is a weak CYP3A inhibitor and may modestly raise ketamine concentrations, and both drugs also cause sedation and can lower blood pressure. This may increase drowsiness, dizziness and orthostatic effects.
How serious is the interaction between Iloperidone and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure during co-use. Reduce the ketamine dose if excessive sedation occurs.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
