Drug interactions
Iloperidone + Lansoprazole
Severity: Minor
Iloperidone and Lansoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is a weak CYP3A inhibitor and may slightly raise lansoprazole levels. Lansoprazole is well tolerated across a wide range of exposures, so the clinical effect is expected to be small.
What this interaction means in plain words
Iloperidone and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Iloperidone belongs to Central Nervous System; Lansoprazole belongs to Gastrointestinal Tract.
Why it happens
Iloperidone weakly inhibits CYP3A4, reducing lansoprazole metabolism.
What to do
No dose adjustment is usually needed; watch for lansoprazole adverse effects such as headache or diarrhea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Lansoprazole?
MediHelp rates the interaction as minor. Iloperidone and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone is a weak CYP3A inhibitor and may slightly raise lansoprazole levels. Lansoprazole is well tolerated across a wide range of exposures, so the clinical effect is expected to be small.
How serious is the interaction between Iloperidone and Lansoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; watch for lansoprazole adverse effects such as headache or diarrhea.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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