Drug interactions
Iloperidone + Meclizine
Severity: Moderate
Iloperidone and Meclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone has sedating and mild anticholinergic properties and also prolongs the QT interval. Meclizine adds to drowsiness and anticholinergic effects, which can worsen dizziness, confusion and orthostatic symptoms.
What this interaction means in plain words
Iloperidone and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Meclizine belongs to Respiratory.
Why it happens
Additive CNS depression and antimuscarinic effects from H1-antihistamine and antipsychotic receptor blockade.
What to do
Monitor sedation, orthostatic blood pressure and anticholinergic effects. Reduce doses if excessive drowsiness occurs and review other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclizine
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Meclizine?
MediHelp rates the interaction as moderate. Iloperidone and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone has sedating and mild anticholinergic properties and also prolongs the QT interval. Meclizine adds to drowsiness and anticholinergic effects, which can worsen dizziness, confusion and orthostatic symptoms.
How serious is the interaction between Iloperidone and Meclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, orthostatic blood pressure and anticholinergic effects. Reduce doses if excessive drowsiness occurs and review other QT-prolonging drugs.
What other medicines interact with Meclizine?
MediHelp also lists interactions of Meclizine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Meclizine page.
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