Drug interactions
Iloperidone + Metformin-sitagliptin
Severity: Moderate
Iloperidone and Metformin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics such as iloperidone are associated with weight gain, insulin resistance and hyperglycemia. This can reduce glycemic control in patients on metformin and sitagliptin.
What this interaction means in plain words
Iloperidone and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Antipsychotic-induced metabolic effects, including insulin resistance and weight gain, oppose antidiabetic therapy.
What to do
Monitor fasting glucose, HbA1c and weight at baseline and regularly during treatment. Intensify the antidiabetic regimen if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Metformin-sitagliptin?
MediHelp rates the interaction as moderate. Iloperidone and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atypical antipsychotics such as iloperidone are associated with weight gain, insulin resistance and hyperglycemia. This can reduce glycemic control in patients on metformin and sitagliptin.
How serious is the interaction between Iloperidone and Metformin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose, HbA1c and weight at baseline and regularly during treatment. Intensify the antidiabetic regimen if control worsens.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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