Drug interactions
Iloperidone + Metformin
Severity: Moderate
Iloperidone and Metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone, an atypical antipsychotic, can cause hyperglycemia and weight gain that may worsen diabetes control. This can offset the benefit of metformin.
What this interaction means in plain words
Iloperidone and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Metformin belongs to Endocrine.
Why it happens
Atypical antipsychotics induce insulin resistance and metabolic disturbance, opposing metformin action (pharmacodynamic antagonism).
What to do
Check fasting glucose and HbA1c at baseline and periodically during iloperidone therapy. Intensify antidiabetic treatment if control deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Metformin?
MediHelp rates the interaction as moderate. Iloperidone and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone, an atypical antipsychotic, can cause hyperglycemia and weight gain that may worsen diabetes control. This can offset the benefit of metformin.
How serious is the interaction between Iloperidone and Metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check fasting glucose and HbA1c at baseline and periodically during iloperidone therapy. Intensify antidiabetic treatment if control deteriorates.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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