Drug interactions
Iloperidone + Phenylephrine
Severity: Moderate
Iloperidone and Phenylephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone blocks alpha-1 adrenoceptors, which can cause orthostatic hypotension, and phenylephrine acts as an alpha-1 agonist. The antipsychotic may therefore blunt the pressor response to phenylephrine, so a larger dose may be needed to achieve the desired blood pressure.
What this interaction means in plain words
Iloperidone and Phenylephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Phenylephrine belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at alpha-1 adrenergic receptors by iloperidone opposing phenylephrine agonism.
What to do
Monitor blood pressure closely when phenylephrine is given for hypotension in a patient on iloperidone and titrate to effect. Avoid using epinephrine for this purpose since unopposed beta effects may worsen hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenylephrine
- Isocarboxazid + Phenylephrine Contraindicated
- Phenelzine + Phenylephrine Contraindicated
- Phenylephrine + Tranylcypromine Contraindicated
- Bromocriptine + Phenylephrine Major
- Cocaine + Phenylephrine Major
- Dihydroergotamine intranasal + Phenylephrine Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Phenylephrine?
MediHelp rates the interaction as moderate. Iloperidone and Phenylephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone blocks alpha-1 adrenoceptors, which can cause orthostatic hypotension, and phenylephrine acts as an alpha-1 agonist. The antipsychotic may therefore blunt the pressor response to phenylephrine, so a larger dose may be needed to achieve the desired blood pressure.
How serious is the interaction between Iloperidone and Phenylephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely when phenylephrine is given for hypotension in a patient on iloperidone and titrate to effect. Avoid using epinephrine for this purpose since unopposed beta effects may worsen hypotension.
What other medicines interact with Phenylephrine?
MediHelp also lists interactions of Phenylephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Phenylephrine page.
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