Drug interactions
Iloperidone + Pirbuterol
Severity: Moderate
Iloperidone and Pirbuterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone prolongs the QT interval and can cause orthostatic hypotension with reflex tachycardia. Beta-agonist induced hypokalemia and tachycardia could add to arrhythmia risk, although clinical data are limited.
What this interaction means in plain words
Iloperidone and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive proarrhythmic potential from QT prolongation and beta-2 mediated hypokalemia.
What to do
Check potassium before and during combined use in patients with cardiac risk factors, and consider ECG monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Pirbuterol?
MediHelp rates the interaction as moderate. Iloperidone and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone prolongs the QT interval and can cause orthostatic hypotension with reflex tachycardia. Beta-agonist induced hypokalemia and tachycardia could add to arrhythmia risk, although clinical data are limited.
How serious is the interaction between Iloperidone and Pirbuterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium before and during combined use in patients with cardiac risk factors, and consider ECG monitoring.
What other medicines interact with Iloperidone?
MediHelp also lists interactions of Iloperidone with, for example, Thioridazine, Alfuzosin, Amiodarone. The full list is on the Iloperidone page.
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