Drug interactions
Iloperidone + Prazosin
Severity: Moderate
Iloperidone and Prazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone blocks alpha-1 adrenergic receptors and can cause orthostatic hypotension, adding to prazosin's effect. Dizziness, syncope and falls are more likely, especially during dose titration.
What this interaction means in plain words
Iloperidone and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Prazosin belongs to Genitourinary.
Why it happens
Additive alpha-1 adrenergic blockade.
What to do
Monitor orthostatic blood pressure during initiation and dose increases. Reduce prazosin dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Prazosin?
MediHelp rates the interaction as moderate. Iloperidone and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone blocks alpha-1 adrenergic receptors and can cause orthostatic hypotension, adding to prazosin's effect. Dizziness, syncope and falls are more likely, especially during dose titration.
How serious is the interaction between Iloperidone and Prazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure during initiation and dose increases. Reduce prazosin dose if symptomatic hypotension occurs.
What other medicines interact with Prazosin?
MediHelp also lists interactions of Prazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Prazosin page.
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