Drug interactions
Iloperidone + Salbutamol
Severity: Moderate
Iloperidone and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone prolongs the QT interval, and salbutamol can add to this effect, especially at high doses or when potassium is low. The combination may raise the risk of ventricular arrhythmias in vulnerable patients.
What this interaction means in plain words
Iloperidone and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Salbutamol belongs to Respiratory.
Why it happens
Additive QT prolongation, with salbutamol-induced hypokalemia as a possible contributor.
What to do
Monitor ECG and serum potassium in patients with cardiac disease or other QT risk factors. Use the lowest effective salbutamol dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Salbutamol?
MediHelp rates the interaction as moderate. Iloperidone and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone prolongs the QT interval, and salbutamol can add to this effect, especially at high doses or when potassium is low. The combination may raise the risk of ventricular arrhythmias in vulnerable patients.
How serious is the interaction between Iloperidone and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium in patients with cardiac disease or other QT risk factors. Use the lowest effective salbutamol dose.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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