Drug interactions
Iloperidone + Theophylline
Severity: Minor
Iloperidone and Theophylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is a weak time-dependent CYP3A4 inhibitor, but theophylline is cleared mainly by CYP1A2, with CYP3A4 playing a minor role. Any rise in theophylline concentrations is expected to be small and clinically unlikely.
What this interaction means in plain words
Iloperidone and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Iloperidone belongs to Central Nervous System; Theophylline belongs to Respiratory.
Why it happens
Weak CYP3A4 inhibition by iloperidone slightly reduces a minor metabolic pathway of theophylline.
What to do
No routine dose change is needed; check theophylline levels if signs of toxicity such as nausea, tremor or tachycardia appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Theophylline?
MediHelp rates the interaction as minor. Iloperidone and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone is a weak time-dependent CYP3A4 inhibitor, but theophylline is cleared mainly by CYP1A2, with CYP3A4 playing a minor role. Any rise in theophylline concentrations is expected to be small and clinically unlikely.
How serious is the interaction between Iloperidone and Theophylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; check theophylline levels if signs of toxicity such as nausea, tremor or tachycardia appear.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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