Drug interactions
Iloperidone + Tofacitinib
Severity: Minor
Iloperidone and Tofacitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is a substrate of CYP3A4 and CYP2D6 with at most weak CYP3A4 inhibition, so a meaningful rise in tofacitinib exposure is not established. The interaction is largely theoretical.
What this interaction means in plain words
Iloperidone and Tofacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Iloperidone belongs to Central Nervous System; Tofacitinib belongs to Musculoskeletal.
Why it happens
Possible weak CYP3A4 inhibition; not clearly established.
What to do
No dose adjustment is needed; monitor for tofacitinib adverse effects as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Tofacitinib?
MediHelp rates the interaction as minor. Iloperidone and Tofacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone is a substrate of CYP3A4 and CYP2D6 with at most weak CYP3A4 inhibition, so a meaningful rise in tofacitinib exposure is not established. The interaction is largely theoretical.
How serious is the interaction between Iloperidone and Tofacitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for tofacitinib adverse effects as usual.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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