Drug interactions
Iloperidone + Topiramate
Severity: Moderate
Iloperidone and Topiramate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation and dizziness, and iloperidone may also cause orthostatic hypotension. Topiramate may also slightly lower iloperidone concentrations through weak CYP3A4 induction, although this is unlikely to be important.
What this interaction means in plain words
Iloperidone and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Topiramate belongs to Central Nervous System.
Why it happens
Additive CNS depression, plus possible weak CYP3A4 induction by topiramate increasing iloperidone metabolism.
What to do
Monitor for excessive sedation, dizziness and orthostatic symptoms, and assess psychiatric response if topiramate is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Iloperidone and Topiramate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Topiramate
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Topiramate?
MediHelp rates the interaction as moderate. Iloperidone and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation and dizziness, and iloperidone may also cause orthostatic hypotension. Topiramate may also slightly lower iloperidone concentrations through weak CYP3A4 induction, although this is unlikely to be important.
How serious is the interaction between Iloperidone and Topiramate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, dizziness and orthostatic symptoms, and assess psychiatric response if topiramate is started or stopped.
What other medicines interact with Topiramate?
MediHelp also lists interactions of Topiramate with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Topiramate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
