Drug interactions
Iloperidone + Venlafaxine
Severity: Moderate
Iloperidone and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone prolongs the QT interval and is cleared by CYP2D6 and CYP3A4. Venlafaxine, a weak CYP2D6 inhibitor, may slightly increase iloperidone levels, and both agents can contribute to QT effects. Iloperidone may in turn modestly raise venlafaxine exposure via CYP3A4 inhibition.
What this interaction means in plain words
Iloperidone and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive QT prolongation with minor CYP2D6 and CYP3A4 inhibition affecting both drugs.
What to do
Monitor ECG and electrolytes, particularly in patients with cardiac risk factors. Monitor for adverse effects of both drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Iloperidone and Venlafaxine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Venlafaxine?
MediHelp rates the interaction as moderate. Iloperidone and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone prolongs the QT interval and is cleared by CYP2D6 and CYP3A4. Venlafaxine, a weak CYP2D6 inhibitor, may slightly increase iloperidone levels, and both agents can contribute to QT effects. Iloperidone may in turn modestly raise venlafaxine exposure via CYP3A4 inhibition.
How serious is the interaction between Iloperidone and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, particularly in patients with cardiac risk factors. Monitor for adverse effects of both drugs.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
