Drug interactions
Iloprost + Remifentanil
Severity: Moderate
Iloprost and Remifentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can lower blood pressure, and with intravenous iloprost the hypotensive effect may be increased. This is mainly relevant in the perioperative setting.
What this interaction means in plain words
Iloprost and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloprost belongs to Cardiovascular; Remifentanil belongs to Musculoskeletal.
Why it happens
Additive hypotensive effects from prostacyclin-mediated vasodilation and opioid-related vasodilation and bradycardia.
What to do
Monitor blood pressure and heart rate, and treat hypotension with fluids as needed. Reduce or pause iloprost if hypotension persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Remifentanil
- Alvimopan + Remifentanil Contraindicated
- Isocarboxazid + Remifentanil Contraindicated
- Olanzapine / samidorphan + Remifentanil Contraindicated
- Phenelzine + Remifentanil Contraindicated
- Benzhydrocodone / acetaminophen + Remifentanil Major
- Brexanolone + Remifentanil Major
Other interactions of Iloprost
- Aldesleukin + Iloprost Moderate
- Amiodarone + Iloprost Moderate
- Bortezomib + Iloprost Moderate
- Bromocriptine + Iloprost Moderate
- Bupivacaine + Iloprost Moderate
- Carbidopa-entacapone-levodopa + Iloprost Moderate
Frequently asked questions
Can I take Iloprost with Remifentanil?
MediHelp rates the interaction as moderate. Iloprost and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can lower blood pressure, and with intravenous iloprost the hypotensive effect may be increased. This is mainly relevant in the perioperative setting.
How serious is the interaction between Iloprost and Remifentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and treat hypotension with fluids as needed. Reduce or pause iloprost if hypotension persists.
What other medicines interact with Remifentanil?
MediHelp also lists interactions of Remifentanil with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Remifentanil page.
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