Drug interactions
Iloprost + Sodium nitroprusside
Severity: Moderate
Iloprost and Sodium nitroprusside: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloprost is a potent prostacyclin vasodilator, and giving it with nitroprusside may produce excessive additive lowering of blood pressure. Intravenous use is of greatest concern because hypotension may be abrupt.
What this interaction means in plain words
Iloprost and Sodium nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloprost belongs to Cardiovascular; Sodium nitroprusside belongs to Cardiovascular.
Why it happens
Additive vasodilation through different pathways: prostacyclin receptor-mediated cAMP increase and nitric oxide-mediated cGMP increase.
What to do
Monitor blood pressure closely and consider temporarily stopping or reducing nitroprusside while iloprost is infused. If hypotension persists, reduce or stop iloprost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sodium nitroprusside
Other interactions of Iloprost
- Aldesleukin + Iloprost Moderate
- Amiodarone + Iloprost Moderate
- Bortezomib + Iloprost Moderate
- Bromocriptine + Iloprost Moderate
- Bupivacaine + Iloprost Moderate
- Carbidopa-entacapone-levodopa + Iloprost Moderate
Frequently asked questions
Can I take Iloprost with Sodium nitroprusside?
MediHelp rates the interaction as moderate. Iloprost and Sodium nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloprost is a potent prostacyclin vasodilator, and giving it with nitroprusside may produce excessive additive lowering of blood pressure. Intravenous use is of greatest concern because hypotension may be abrupt.
How serious is the interaction between Iloprost and Sodium nitroprusside?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely and consider temporarily stopping or reducing nitroprusside while iloprost is infused. If hypotension persists, reduce or stop iloprost.
What other medicines interact with Sodium nitroprusside?
MediHelp also lists interactions of Sodium nitroprusside with, for example, Avanafil, Nitric oxide, Sildenafil. The full list is on the Sodium nitroprusside page.
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