Drug interactions
Imatinib + Istradefylline
Severity: Moderate
Imatinib and Istradefylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg daily istradefylline increases exposure to CYP3A4 and P-glycoprotein substrates, which may raise imatinib levels. This may amplify imatinib adverse effects. The effect is not seen at 20 mg daily.
What this interaction means in plain words
Imatinib and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline at higher doses inhibits CYP3A4 and P-glycoprotein, reducing imatinib clearance.
What to do
Keep istradefylline at 20 mg daily where possible and monitor for imatinib toxicity, adjusting the imatinib dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Imatinib with Istradefylline?
MediHelp rates the interaction as moderate. Imatinib and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At 40 mg daily istradefylline increases exposure to CYP3A4 and P-glycoprotein substrates, which may raise imatinib levels. This may amplify imatinib adverse effects. The effect is not seen at 20 mg daily.
How serious is the interaction between Imatinib and Istradefylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep istradefylline at 20 mg daily where possible and monitor for imatinib toxicity, adjusting the imatinib dose if needed.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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