Drug interactions
Imatinib + Ivosidenib
Severity: Moderate
Imatinib and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower imatinib concentrations, risking loss of efficacy in CML or GIST. Imatinib may also increase ivosidenib exposure by inhibiting CYP3A4, which could raise QT risk.
What this interaction means in plain words
Imatinib and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Ivosidenib belongs to Oncology.
Why it happens
Ivosidenib induces CYP3A4 (and CYP2C9) and may reduce imatinib exposure; imatinib may inhibit ivosidenib metabolism.
What to do
Monitor imatinib response and consider plasma level monitoring, and monitor ECG for QT prolongation; an imatinib dose increase may be needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Imatinib with Ivosidenib?
MediHelp rates the interaction as moderate. Imatinib and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower imatinib concentrations, risking loss of efficacy in CML or GIST. Imatinib may also increase ivosidenib exposure by inhibiting CYP3A4, which could raise QT risk.
How serious is the interaction between Imatinib and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor imatinib response and consider plasma level monitoring, and monitor ECG for QT prolongation; an imatinib dose increase may be needed.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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