Drug interactions
Imatinib + Larotrectinib
Severity: Moderate
Imatinib and Larotrectinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is mainly metabolized by CYP3A4, so imatinib may increase its exposure. Increased exposure may worsen adverse effects such as hepatotoxicity, dizziness and neurotoxicity.
What this interaction means in plain words
Imatinib and Larotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Larotrectinib belongs to Oncology.
Why it happens
Imatinib inhibits CYP3A4-mediated metabolism of larotrectinib.
What to do
Monitor liver enzymes and neurologic adverse effects; reduce larotrectinib dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Larotrectinib
Frequently asked questions
Can I take Imatinib with Larotrectinib?
MediHelp rates the interaction as moderate. Imatinib and Larotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Larotrectinib is mainly metabolized by CYP3A4, so imatinib may increase its exposure. Increased exposure may worsen adverse effects such as hepatotoxicity, dizziness and neurotoxicity.
How serious is the interaction between Imatinib and Larotrectinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and neurologic adverse effects; reduce larotrectinib dose if toxicity develops.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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