Drug interactions
Imatinib + Lefamulin
Severity: Moderate
Imatinib and Lefamulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin is a CYP3A4 and P-gp substrate and imatinib may increase its exposure. This could increase QT prolongation risk, which is a known effect of lefamulin. Lefamulin may also raise imatinib levels via CYP3A4 inhibition.
What this interaction means in plain words
Imatinib and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Lefamulin belongs to Anti Bacterial.
Why it happens
Imatinib inhibits CYP3A4 metabolism of lefamulin, raising its plasma concentration.
What to do
Monitor for adverse effects and consider ECG monitoring for QTc prolongation, especially with other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Imatinib with Lefamulin?
MediHelp rates the interaction as moderate. Imatinib and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lefamulin is a CYP3A4 and P-gp substrate and imatinib may increase its exposure. This could increase QT prolongation risk, which is a known effect of lefamulin. Lefamulin may also raise imatinib levels via CYP3A4 inhibition.
How serious is the interaction between Imatinib and Lefamulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects and consider ECG monitoring for QTc prolongation, especially with other QT-prolonging drugs.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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