Drug interactions
Imatinib + Macitentan
Severity: Moderate
Imatinib and Macitentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib may modestly raise macitentan and its active metabolite levels through CYP3A4 inhibition. This may increase risks such as hypotension, anemia, edema and hepatic effects.
What this interaction means in plain words
Imatinib and Macitentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Macitentan belongs to Cardiovascular.
Why it happens
Imatinib inhibits CYP3A4, which metabolizes macitentan.
What to do
Monitor blood pressure, hemoglobin and liver enzymes. Consider an alternative if tolerability problems appear, since labeling advises against strong CYP3A4 inhibitors and imatinib is only moderate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Imatinib and Macitentan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Macitentan
- Amiodarone + Macitentan Major
- Apalutamide + Macitentan Major
- Bosentan + Macitentan Major
- Carbamazepine + Macitentan Major
- Clarithromycin + Macitentan Major
- Efavirenz + Macitentan Major
Frequently asked questions
Can I take Imatinib with Macitentan?
MediHelp rates the interaction as moderate. Imatinib and Macitentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib may modestly raise macitentan and its active metabolite levels through CYP3A4 inhibition. This may increase risks such as hypotension, anemia, edema and hepatic effects.
How serious is the interaction between Imatinib and Macitentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, hemoglobin and liver enzymes. Consider an alternative if tolerability problems appear, since labeling advises against strong CYP3A4 inhibitors and imatinib is only moderate.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
