Drug interactions
Imatinib + Mavacamten
Severity: Major
Imatinib and Mavacamten: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten is metabolized mainly by CYP2C19 and CYP3A4, and imatinib inhibits CYP3A4 (and possibly CYP2C19). Higher mavacamten exposure may reduce ejection fraction and cause heart failure from systolic dysfunction.
What this interaction means in plain words
Imatinib and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Imatinib belongs to Oncology; Mavacamten belongs to Cardiovascular.
Why it happens
Imatinib inhibits CYP3A4 and may inhibit CYP2C19, decreasing mavacamten clearance.
What to do
Check LVEF by echocardiography and adjust the mavacamten dose, with closer monitoring when imatinib is started or stopped. Consider an alternative to imatinib if left ventricular function declines.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Imatinib with Mavacamten?
MediHelp rates the interaction as major. Imatinib and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mavacamten is metabolized mainly by CYP2C19 and CYP3A4, and imatinib inhibits CYP3A4 (and possibly CYP2C19). Higher mavacamten exposure may reduce ejection fraction and cause heart failure from systolic dysfunction.
How serious is the interaction between Imatinib and Mavacamten?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check LVEF by echocardiography and adjust the mavacamten dose, with closer monitoring when imatinib is started or stopped. Consider an alternative to imatinib if left ventricular function declines.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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