Drug interactions
Imatinib + Meclofenamic acid
Severity: Moderate
Imatinib and Meclofenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib can cause thrombocytopenia and bleeding, and NSAIDs add platelet dysfunction and gastrointestinal irritation. The combination increases bleeding risk.
What this interaction means in plain words
Imatinib and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Meclofenamic acid belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic effect of imatinib-related thrombocytopenia and NSAID platelet inhibition and mucosal injury.
What to do
Monitor complete blood counts including platelets and watch for bleeding signs. Prefer paracetamol for analgesia, especially if platelet counts are low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Meclofenamic acid?
MediHelp rates the interaction as moderate. Imatinib and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib can cause thrombocytopenia and bleeding, and NSAIDs add platelet dysfunction and gastrointestinal irritation. The combination increases bleeding risk.
How serious is the interaction between Imatinib and Meclofenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts including platelets and watch for bleeding signs. Prefer paracetamol for analgesia, especially if platelet counts are low.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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