Drug interactions
Imatinib + Morphine
Severity: Minor
Imatinib and Morphine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP2D6, but morphine depends mainly on glucuronidation, so a clinically important increase in exposure is unlikely. Any effect is expected to be small.
What this interaction means in plain words
Imatinib and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imatinib belongs to Oncology; Morphine belongs to Musculoskeletal.
Why it happens
Theoretical CYP2D6 inhibition by imatinib with little relevance to morphine clearance.
What to do
No dose adjustment is usually required; monitor analgesia and sedation as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Morphine?
MediHelp rates the interaction as minor. Imatinib and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Imatinib inhibits CYP2D6, but morphine depends mainly on glucuronidation, so a clinically important increase in exposure is unlikely. Any effect is expected to be small.
How serious is the interaction between Imatinib and Morphine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required; monitor analgesia and sedation as usual.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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