Drug interactions
Imatinib + Nateglinide
Severity: Moderate
Imatinib and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP2C9 and CYP3A4 and may raise nateglinide levels. This could strengthen glucose lowering and increase hypoglycemia risk. Imatinib itself can also alter glucose levels in diabetic patients.
What this interaction means in plain words
Imatinib and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Nateglinide belongs to Endocrine.
Why it happens
Imatinib inhibits CYP2C9 and CYP3A4, reducing nateglinide metabolism.
What to do
Monitor blood glucose after imatinib is started or the dose is changed, and reduce the nateglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Nateglinide?
MediHelp rates the interaction as moderate. Imatinib and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib inhibits CYP2C9 and CYP3A4 and may raise nateglinide levels. This could strengthen glucose lowering and increase hypoglycemia risk. Imatinib itself can also alter glucose levels in diabetic patients.
How serious is the interaction between Imatinib and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after imatinib is started or the dose is changed, and reduce the nateglinide dose if hypoglycemia occurs.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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