Drug interactions
Imatinib + Nifedipine
Severity: Moderate
Imatinib and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP3A4 and can raise nifedipine levels, which may cause hypotension and edema. Imatinib itself can cause fluid retention, which complicates assessment of edema.
What this interaction means in plain words
Imatinib and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Nifedipine belongs to Cardiovascular.
Why it happens
Imatinib inhibits CYP3A4 and may reduce nifedipine metabolism; nifedipine has little clinical effect on imatinib.
What to do
Monitor blood pressure and edema, and reduce the nifedipine dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Nifedipine?
MediHelp rates the interaction as moderate. Imatinib and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib inhibits CYP3A4 and can raise nifedipine levels, which may cause hypotension and edema. Imatinib itself can cause fluid retention, which complicates assessment of edema.
How serious is the interaction between Imatinib and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema, and reduce the nifedipine dose if hypotension occurs.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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