Drug interactions
Imatinib + Norgestrel
Severity: Minor
Imatinib and Norgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib is a moderate CYP3A4 inhibitor and may raise norgestrel concentrations. This could increase progestogenic adverse effects, although the clinical impact is probably modest. Imatinib is also teratogenic, so reliable contraception matters in treated patients.
What this interaction means in plain words
Imatinib and Norgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imatinib belongs to Oncology; Norgestrel belongs to Endocrine.
Why it happens
Imatinib inhibits CYP3A4-mediated metabolism of norgestrel.
What to do
No routine dose change is needed; monitor for progestogenic adverse effects such as breakthrough bleeding, headache or mood changes. Continue effective contraception during imatinib therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Imatinib and Norgestrel, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Norgestrel
- Amobarbital + Norgestrel Major
- Apalutamide + Norgestrel Major
- Bosentan + Norgestrel Major
- Carbamazepine + Norgestrel Major
- Efavirenz + Norgestrel Major
- Enzalutamide + Norgestrel Major
Frequently asked questions
Can I take Imatinib with Norgestrel?
MediHelp rates the interaction as minor. Imatinib and Norgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Imatinib is a moderate CYP3A4 inhibitor and may raise norgestrel concentrations. This could increase progestogenic adverse effects, although the clinical impact is probably modest. Imatinib is also teratogenic, so reliable contraception matters in treated patients.
How serious is the interaction between Imatinib and Norgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for progestogenic adverse effects such as breakthrough bleeding, headache or mood changes. Continue effective contraception during imatinib therapy.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
