Drug interactions
Imatinib + Palifermin
Severity: Minor
Imatinib and Palifermin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin stimulates epithelial cell growth, and labeling advises against giving it close to cytotoxic chemotherapy because it may worsen mucositis. Imatinib is a targeted kinase inhibitor rather than a classic cytotoxic, and this effect is not established with it.
What this interaction means in plain words
Imatinib and Palifermin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imatinib belongs to Oncology; Palifermin belongs to Miscellaneous.
Why it happens
No established mechanism for imatinib; the concern is extrapolated from epithelial proliferation by palifermin during cytotoxic therapy.
What to do
No specific action is usually needed. Follow the palifermin timing guidance if cytotoxic agents are also given.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Palifermin
Frequently asked questions
Can I take Imatinib with Palifermin?
MediHelp rates the interaction as minor. Imatinib and Palifermin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Palifermin stimulates epithelial cell growth, and labeling advises against giving it close to cytotoxic chemotherapy because it may worsen mucositis. Imatinib is a targeted kinase inhibitor rather than a classic cytotoxic, and this effect is not established with it.
How serious is the interaction between Imatinib and Palifermin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is usually needed. Follow the palifermin timing guidance if cytotoxic agents are also given.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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