Drug interactions
Imatinib + Palovarotene
Severity: Moderate
Imatinib and Palovarotene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP3A4 to a moderate degree and can raise palovarotene concentrations. Higher exposure may increase retinoid-related toxicities such as mucocutaneous effects, premature epiphyseal closure in growing children, and bone changes.
What this interaction means in plain words
Imatinib and Palovarotene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Palovarotene belongs to Miscellaneous.
Why it happens
Imatinib inhibits CYP3A4-mediated metabolism of palovarotene, which is a CYP3A substrate.
What to do
Avoid the combination where possible; if it cannot be avoided, reduce the palovarotene dose by about half as labeled. Monitor for retinoid adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Palovarotene
- Acitretin + Palovarotene Contraindicated
- Isotretinoin + Palovarotene Contraindicated
- Amiodarone + Palovarotene Major
- Amobarbital + Palovarotene Major
- Apalutamide + Palovarotene Major
- Aprepitant + Palovarotene Major
Frequently asked questions
Can I take Imatinib with Palovarotene?
MediHelp rates the interaction as moderate. Imatinib and Palovarotene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib inhibits CYP3A4 to a moderate degree and can raise palovarotene concentrations. Higher exposure may increase retinoid-related toxicities such as mucocutaneous effects, premature epiphyseal closure in growing children, and bone changes.
How serious is the interaction between Imatinib and Palovarotene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if it cannot be avoided, reduce the palovarotene dose by about half as labeled. Monitor for retinoid adverse effects.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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