Drug interactions
Imatinib + Paroxetine
Severity: Minor
Imatinib and Paroxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP2D6 in vitro and may modestly raise paroxetine levels. Clinically meaningful effects are uncertain and likely small.
What this interaction means in plain words
Imatinib and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imatinib belongs to Oncology; Paroxetine belongs to Central Nervous System.
Why it happens
Imatinib inhibition of CYP2D6 may reduce paroxetine clearance, though paroxetine already auto-inhibits this enzyme.
What to do
Monitor for paroxetine adverse effects such as nausea and sedation and adjust the dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Paroxetine?
MediHelp rates the interaction as minor. Imatinib and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Imatinib inhibits CYP2D6 in vitro and may modestly raise paroxetine levels. Clinically meaningful effects are uncertain and likely small.
How serious is the interaction between Imatinib and Paroxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for paroxetine adverse effects such as nausea and sedation and adjust the dose if needed.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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