Drug interactions
Imatinib + Pimavanserin
Severity: Moderate
Imatinib and Pimavanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib may raise pimavanserin concentrations through CYP3A4 inhibition, increasing the risk of QT prolongation. Both drugs have been linked to QT effects.
What this interaction means in plain words
Imatinib and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Pimavanserin belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition by imatinib reduces pimavanserin clearance, with possible additive QT effects.
What to do
Consider reducing the pimavanserin dose and monitor ECG, especially with other QT-prolonging risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Frequently asked questions
Can I take Imatinib with Pimavanserin?
MediHelp rates the interaction as moderate. Imatinib and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib may raise pimavanserin concentrations through CYP3A4 inhibition, increasing the risk of QT prolongation. Both drugs have been linked to QT effects.
How serious is the interaction between Imatinib and Pimavanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the pimavanserin dose and monitor ECG, especially with other QT-prolonging risk factors.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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