Drug interactions
Imatinib + Siponimod
Severity: Moderate
Imatinib and Siponimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib is a moderate CYP3A4 inhibitor and may modestly raise siponimod concentrations. Siponimod is cleared mainly by CYP2C9, so the effect is likely clinically significant only when a CYP2C9 inhibitor is also given or the patient is a CYP2C9 poor metabolizer.
What this interaction means in plain words
Imatinib and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Siponimod belongs to Central Nervous System.
Why it happens
Imatinib inhibits CYP3A4, reducing the secondary clearance pathway of siponimod.
What to do
Avoid adding a CYP2C9 inhibitor to this combination. Monitor heart rate, liver enzymes and lymphocyte counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Siponimod?
MediHelp rates the interaction as moderate. Imatinib and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib is a moderate CYP3A4 inhibitor and may modestly raise siponimod concentrations. Siponimod is cleared mainly by CYP2C9, so the effect is likely clinically significant only when a CYP2C9 inhibitor is also given or the patient is a CYP2C9 poor metabolizer.
How serious is the interaction between Imatinib and Siponimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid adding a CYP2C9 inhibitor to this combination. Monitor heart rate, liver enzymes and lymphocyte counts.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
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