Drug interactions
Imatinib + Sotorasib
Severity: Moderate
Imatinib and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a P-gp inhibitor in vitro and may alter imatinib transport. It can also induce CYP3A4, so net effects on imatinib exposure are uncertain, and clinical significance is not established.
What this interaction means in plain words
Imatinib and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Sotorasib belongs to Oncology.
Why it happens
Sotorasib may affect P-gp efflux and weakly induce CYP3A4, but the net effect on imatinib is not well established.
What to do
Monitor imatinib response and adverse effects such as edema and cytopenias. Consider imatinib trough levels if available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Imatinib with Sotorasib?
MediHelp rates the interaction as moderate. Imatinib and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib is a P-gp inhibitor in vitro and may alter imatinib transport. It can also induce CYP3A4, so net effects on imatinib exposure are uncertain, and clinical significance is not established.
How serious is the interaction between Imatinib and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor imatinib response and adverse effects such as edema and cytopenias. Consider imatinib trough levels if available.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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