Drug interactions
Imatinib + Suvorexant
Severity: Moderate
Imatinib and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP3A4 to a moderate degree and can raise suvorexant plasma concentrations. Higher exposure may cause greater next-day somnolence, impaired alertness and driving impairment.
What this interaction means in plain words
Imatinib and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Suvorexant belongs to Central Nervous System.
Why it happens
Imatinib inhibits CYP3A4-mediated metabolism of suvorexant, which is a CYP3A4 substrate.
What to do
Use the lowest suvorexant dose, with the labeled reduction when a moderate CYP3A4 inhibitor is given. Counsel on next-day drowsiness and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Suvorexant
Frequently asked questions
Can I take Imatinib with Suvorexant?
MediHelp rates the interaction as moderate. Imatinib and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib inhibits CYP3A4 to a moderate degree and can raise suvorexant plasma concentrations. Higher exposure may cause greater next-day somnolence, impaired alertness and driving impairment.
How serious is the interaction between Imatinib and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest suvorexant dose, with the labeled reduction when a moderate CYP3A4 inhibitor is given. Counsel on next-day drowsiness and driving.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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