Drug interactions
Imatinib + Timolol
Severity: Moderate
Imatinib and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP2D6 and may raise timolol concentrations, increasing beta-blocker effects such as bradycardia and hypotension. The clinical effect is probably modest and is more relevant with oral timolol.
What this interaction means in plain words
Imatinib and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Timolol belongs to Cardiovascular.
Why it happens
Inhibition of CYP2D6-mediated timolol metabolism by imatinib.
What to do
Monitor heart rate and blood pressure after imatinib is started. Reduce the timolol dose if excessive beta-blockade develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Timolol?
MediHelp rates the interaction as moderate. Imatinib and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib inhibits CYP2D6 and may raise timolol concentrations, increasing beta-blocker effects such as bradycardia and hypotension. The clinical effect is probably modest and is more relevant with oral timolol.
How serious is the interaction between Imatinib and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure after imatinib is started. Reduce the timolol dose if excessive beta-blockade develops.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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