Drug interactions
Imatinib + Tolterodine
Severity: Minor
Imatinib and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP2D6 and CYP3A4 and may increase tolterodine concentrations. Because tolterodine has two parallel clearance pathways, the effect is generally small, but anticholinergic effects may increase.
What this interaction means in plain words
Imatinib and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imatinib belongs to Oncology; Tolterodine belongs to Genitourinary.
Why it happens
Inhibition of CYP2D6 and CYP3A4 metabolism of tolterodine by imatinib.
What to do
Monitor for anticholinergic adverse effects and reduce the tolterodine dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Tolterodine?
MediHelp rates the interaction as minor. Imatinib and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Imatinib inhibits CYP2D6 and CYP3A4 and may increase tolterodine concentrations. Because tolterodine has two parallel clearance pathways, the effect is generally small, but anticholinergic effects may increase.
How serious is the interaction between Imatinib and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and reduce the tolterodine dose if they occur.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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