Drug interactions
Imidapril + Insulin detemir
Severity: Moderate
Imidapril and Insulin detemir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can enhance insulin sensitivity and have been associated with episodes of hypoglycemia in insulin-treated patients, mainly after starting therapy. The effect is usually modest.
What this interaction means in plain words
Imidapril and Insulin detemir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imidapril belongs to Cardiovascular; Insulin detemir belongs to Endocrine.
Why it happens
ACE inhibition may improve insulin sensitivity, possibly through increased bradykinin, adding to insulin's glucose-lowering effect.
What to do
Monitor blood glucose when starting or adjusting imidapril and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin detemir
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Imidapril with Insulin detemir?
MediHelp rates the interaction as moderate. Imidapril and Insulin detemir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can enhance insulin sensitivity and have been associated with episodes of hypoglycemia in insulin-treated patients, mainly after starting therapy. The effect is usually modest.
How serious is the interaction between Imidapril and Insulin detemir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or adjusting imidapril and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin detemir?
MediHelp also lists interactions of Insulin detemir with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin detemir page.
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