Drug interactions
Imidapril + Insulin lispro
Severity: Moderate
Imidapril and Insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and have been associated with more frequent hypoglycemia in patients using insulin. The effect is usually modest but may appear soon after starting the ACE inhibitor.
What this interaction means in plain words
Imidapril and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imidapril belongs to Cardiovascular; Insulin lispro belongs to Endocrine.
Why it happens
ACE inhibition may increase insulin sensitivity, possibly via bradykinin-mediated enhanced glucose uptake.
What to do
Monitor blood glucose when imidapril is started or the dose is raised, and reduce insulin if hypoglycemia occurs. Inform the patient about symptoms of low blood glucose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin lispro
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Imidapril with Insulin lispro?
MediHelp rates the interaction as moderate. Imidapril and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and have been associated with more frequent hypoglycemia in patients using insulin. The effect is usually modest but may appear soon after starting the ACE inhibitor.
How serious is the interaction between Imidapril and Insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when imidapril is started or the dose is raised, and reduce insulin if hypoglycemia occurs. Inform the patient about symptoms of low blood glucose.
What other medicines interact with Insulin lispro?
MediHelp also lists interactions of Insulin lispro with, for example, Alogliptin-pioglitazone, Ethanol, Metreleptin. The full list is on the Insulin lispro page.
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