Drug interactions
Imidapril + Ketorolac
Severity: Moderate
Imidapril and Ketorolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac can reduce the antihypertensive effect of ACE inhibitors such as imidapril and, together, they raise the risk of acute kidney injury and hyperkalemia. The risk is greater in elderly, dehydrated or renally impaired patients.
What this interaction means in plain words
Imidapril and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imidapril belongs to Cardiovascular; Ketorolac belongs to Musculoskeletal.
Why it happens
NSAID inhibition of vasodilatory prostaglandins reduces ACE inhibitor effect and impairs renal perfusion, which depends on efferent arteriolar dilatation.
What to do
Keep ketorolac courses short, ensure hydration, and monitor blood pressure, creatinine and potassium. Consider alternative analgesia in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Imidapril with Ketorolac?
MediHelp rates the interaction as moderate. Imidapril and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac can reduce the antihypertensive effect of ACE inhibitors such as imidapril and, together, they raise the risk of acute kidney injury and hyperkalemia. The risk is greater in elderly, dehydrated or renally impaired patients.
How serious is the interaction between Imidapril and Ketorolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep ketorolac courses short, ensure hydration, and monitor blood pressure, creatinine and potassium. Consider alternative analgesia in high-risk patients.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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