Drug interactions
Imidapril + Metformin-sitagliptin
Severity: Moderate
Imidapril and Metformin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can enhance insulin sensitivity and occasionally lead to hypoglycemia in patients on antidiabetic therapy. They may also reduce renal function, which can raise metformin levels and the risk of lactic acidosis. Sitagliptin has a small added risk of angioedema with ACE inhibitors.
What this interaction means in plain words
Imidapril and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imidapril belongs to Cardiovascular; Metformin-sitagliptin belongs to Endocrine.
Why it happens
ACE inhibition improves insulin sensitivity, and any resulting reduction in renal function reduces metformin and sitagliptin clearance.
What to do
Monitor renal function and blood glucose after starting or changing imidapril, and reduce the antidiabetic dose if eGFR falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Imidapril and Metformin-sitagliptin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Metformin-sitagliptin
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Imidapril with Metformin-sitagliptin?
MediHelp rates the interaction as moderate. Imidapril and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can enhance insulin sensitivity and occasionally lead to hypoglycemia in patients on antidiabetic therapy. They may also reduce renal function, which can raise metformin levels and the risk of lactic acidosis. Sitagliptin has a small added risk of angioedema with ACE inhibitors.
How serious is the interaction between Imidapril and Metformin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and blood glucose after starting or changing imidapril, and reduce the antidiabetic dose if eGFR falls.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
