Drug interactions
Imidapril + Metformin
Severity: Moderate
Imidapril and Metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and have been associated with an increased risk of hypoglycemia in patients on antidiabetic drugs. They may also reduce renal function in some patients, which can promote metformin accumulation and lactic acidosis.
What this interaction means in plain words
Imidapril and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imidapril belongs to Cardiovascular; Metformin belongs to Endocrine.
Why it happens
Additive glucose-lowering via improved insulin sensitivity, and possible renal function decline that reduces metformin clearance.
What to do
Monitor blood glucose and renal function, especially at initiation and after dose changes. Hold metformin if renal function deteriorates significantly or in acute illness with dehydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Imidapril with Metformin?
MediHelp rates the interaction as moderate. Imidapril and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and have been associated with an increased risk of hypoglycemia in patients on antidiabetic drugs. They may also reduce renal function in some patients, which can promote metformin accumulation and lactic acidosis.
How serious is the interaction between Imidapril and Metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function, especially at initiation and after dose changes. Hold metformin if renal function deteriorates significantly or in acute illness with dehydration.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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