Drug interactions
Imipramine + Ipratropium-salbutamol
Severity: Moderate
Imipramine and Ipratropium-salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine can potentiate the cardiovascular effects of salbutamol, leading to tachycardia, palpitations or arrhythmias. Its anticholinergic effects can also add to ipratropium.
What this interaction means in plain words
Imipramine and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Tricyclic blockade of norepinephrine reuptake plus additive proarrhythmic and anticholinergic effects.
What to do
Monitor heart rate and rhythm and the frequency of salbutamol use. Reduce beta-agonist dosing if cardiovascular symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Ipratropium-salbutamol?
MediHelp rates the interaction as moderate. Imipramine and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine can potentiate the cardiovascular effects of salbutamol, leading to tachycardia, palpitations or arrhythmias. Its anticholinergic effects can also add to ipratropium.
How serious is the interaction between Imipramine and Ipratropium-salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and rhythm and the frequency of salbutamol use. Reduce beta-agonist dosing if cardiovascular symptoms occur.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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